Autoimmune epitopes in messenger RNA

Messenger RNA.

Myocarditogenic epitopes and autoimmune myocarditis.

Experimental autoimmune myocarditis is provoked by immunization with cardiac myosin. This animal model finally develops into dilated cardiomyopathy through repetitive myosin injections. To identify the myocardiogenic epitope, therefore, it is imperative not only to understand the mechanism of induction, but also to produce specific therapies, such as a blocking therapy to suppress the autoimmun...

Messenger RNA in animal cells.

It is difficult to believe that only 2 years ago, the very existence of messenger RNAs in animal cells was doubtful, and no definitive example of an isolated and purified mRNA could be given. Since that time, the mRNAs for globin (from rabbit, man, mouse, duck, and guinea pig), lens crystallin (chick and cow), ovalbumin, myosin, and silk fibroin have been isolated and their identities confirmed...

Who discovered messenger RNA?

The announcement of the discovery of messenger RNA (mRNA) and the cracking of the genetic code took place within weeks of each other in a climax of scientific excitement during the summer of 1961. Although mRNA is of decisive importance to our understanding of gene function, no Nobel Prize was awarded for its discovery. The large number of people involved, the complex nature of the results, and...

Haemoglobin messenger RNA.

This is a short review on the isolation and translation in heterologous Systems of a 9 s RNA which carries the information of haemoglobin. Rabbit haemodobin (Hb) messenger RNA (mRNA) was the first eukaryotic genetic message to be isolated, quite a long time ago (1). This was mainly due to the fact that mammalian reticulocytes offer the favourable opportunity of being highly specialized cells wh...